Emerging Cell and Gene Therapy Approaches for Knee Osteoarthritis

ABOUT THE WEBINAR

This webinar, Emerging Cell and Gene Therapy Approaches for Knee Osteoarthritis, will provide participants with an up-to-date overview of how advanced cell and gene therapy (CGT) modalities are being developed to address unmet clinical needs in knee osteoarthritis. The program integrates scientific, translational, and clinical perspectives to highlight emerging disease-modifying strategies beyond conventional symptomatic treatments.

By the end of this webinar, participants will be able to understand the biological rationale for CGT in knee osteoarthritis, including mechanisms related to cartilage degeneration, inflammation, and impaired tissue repair; compare emerging cell-based platforms, such as mesenchymal stromal cells, iPSC-derived products, and extracellular vesicles, with respect to mechanism of action and translational potential; and recognize key gene therapy strategies being explored for local joint delivery. Participants will also gain insight into critical manufacturing, clinical trial, and regulatory considerations that influence the development, evaluation, and future adoption of CGT-based therapies for knee osteoarthritis.

KEY LEARNING OBJECTIVES

  • Describe the biological rationale for applying cell and gene therapy in knee osteoarthritis.
  • Compare and critically evaluate emerging cell-based therapeutic platforms.
  • Understand gene therapy approaches under investigation for OA.
  • Identify key translational and manufacturing challenges.
  • Interpret current clinical trial designs, endpoints, and regulatory considerations.
 WEBINAR CHAIRS

Oscar Lee, MD, PhD, MSc
ISCT MSK Committee Chair
Professor and Senior Consultant
Mackay Memorial Hospital
Taiwan

 WEBINAR SPEAKERS

Scott Rodeo, MD
 ISCT MSK Committee Member
Professor, Orthopaedic Surgery
The Hospital for Special Surgey
United States

Christopher Evans, PhD
 Professor of Orthopaedics
Mayo Clinic
United States

Ichiro Sekiya, MD, PhD
Director
Center for Stem Cell and Regenerative Medicine
Institute of Science, Tokyo
Japan

Brian Cole, MD, MBA
 Sports Medicine Orthopedic Surgeon
Professor, Acting Chair and Managing Partner, Dpt. of Orthopaedics
Rush University Medical Center
United States

Daniel Grande, PhD
Professor, Dpt. of Orthopedic Surgery and Molecular Medicine
The Feinstein Institutes for Medical Research
Northwell Health and Zucker School of Medicine
United States