Dr. Muschler is a Professor of Orthopaedic Surgery and Biomedical Engineering at the Cleveland Clinic, with a clinical practice that integrates joint replacement, joint preservation, and bone and cartilage repair.
Dr. Muschler’s Regenerative Medicine Laboratory has earned continuous federal funding for over 25 years, focusing on stem and progenitor cell biology, tissue engineering and regenerative medicine. He has served as Vice Chair of Bioengineering (2004-2013); Director of the Orthopaedic Research Center (2005-2013), Vice Chair of the Orthopaedic and Rheumatologic Institute (2007-2013) and has served as Director of the Cleveland Clinic Joint Preservation Center since 2017.
Dr. Muschler led the development of several multi-institutional collaborative translational networks. He founded and led the Ohio-based Clinical Tissue Engineering Center (2005-2012), and served as the founding Co-Director of the Armed Forces Institute of Regenerative Medicine (AFIRM) (2008-2011), dedicated to the accelerated development of therapies to serve wounded warriors.
Quantitative imaging and automation technology developed by Dr. Muschler’s team was spun off by the Cleveland Clinic in 2019 to form Cell X Technologies, Inc. Cell X focuses on transformation of cell sourcing and automated fabrication systems to accelerate the development of safe, effective, and affordable cellular therapies and cell-based products.
Dr. Muschler is currently Co-Chair of the Orthopedic and Musculoskeletal Therapies Committee of the International Society for Cell & Gene Therapy (ISCT), and served as Co-Chair of the 2021 ISCT Annual meeting.