Cell and gene therapy for CD4+ T-cell transduction shows great potential for a functional cure for human immunodeficiency virus (HIV) infection, a global pandemic affecting almost 40 million persons worldwide, with 40 million deaths since its start over 40 years ago. While highly active antiretroviral therapy (HAART) has greatly improved the quality of life, morbidity, and survival of HIV-positive patients since its development, issues with medication adherence, adverse effects, drug resistance, and long-term treatment costs are some of its major problems. Cell and gene-based therapies for a functional cure of HIV may accomplish the eventual goal of disease eradication. Read More